# PhenoAge

PhenoAge is a composite measure of your biological age. Levine and colleagues developed it in 2018. The original version is blood-based. It blends nine clinical markers with your chronological age, calibrated against death risk. Those markers include albumin, creatinine, glucose, C-reactive protein, and white blood cell count. There is also a DNA-methylation version, called DNAm PhenoAge. It ports the score onto epigenetic data. PhenoAge predicts all-cause death and multimorbidity better than chronological age alone. It has been validated in several large cohorts. But its clinical use is still emerging.

## Sources

- Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). https://doi.org/10.18632/aging.101414

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_Canonical: https://longevity-austria.com/en/glossary/phenoage · Part of Longevity Cities · Updated 2026-06-22_