# Plasmapheresis

Plasmapheresis is the umbrella term for procedures that separate the plasma from the cells in your blood, outside your body. The technique varies. The plasma can be filtered and partly returned. Or it can be fully removed and replaced (as in 'therapeutic plasma exchange', TPE). It is established for autoimmune and 'hyperviscosity' disorders. There, its main job is removing harmful plasma factors. Those include antibodies, immune complexes, and inflammatory mediators. In longevity circles, it is proposed to dilute pro-aging factors in your plasma. But the evidence for a healthy-aging benefit is still preliminary.

## Sources

- Kim D, Kiprov DD, Luellen C et al.. (2022). Old plasma dilution reduces human biological age: a clinical study. GeroScience. https://doi.org/10.1007/s11357-022-00645-w
- Mehdipour M, Etienne J, Liu C, Mehdipour T, Kato C, Conboy M, Conboy I, Kiprov DD. (2021). Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach. Transfusion and Apheresis Science. https://doi.org/10.1016/j.transci.2021.103162

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_Canonical: https://longevity-austria.com/en/glossary/plasmapheresis · Part of Longevity Cities · Updated 2026-06-22_