# Fasting vs. Cutting Calories: Which One Really Fights Aging in Fatty Liver?

*Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article, Clinical Trial Protocol
- **Journal**: Frontiers in endocrinology
- **Sample Size**: 177 adults aged 50-70 with overweight/obesity and early fatty liver disease
- **Authors**: Celada-Guerrero JA, Rubio-Gordón L, Jiménez-Perez Y, López-Lora L, López-González A, Delbuono S, Huertas A, Martínez-Urbistondo D, Ordovás JM, de la O V, Daimiel L
- **Published**: 2026-06-12
- **Topics**: time-restricted eating, calorie restriction, fatty liver
- **DOI**: https://doi.org/10.3389/fendo.2026.1849550
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42369048/

## Summary

Researchers want to know if eating in a shorter daily window works as well as cutting calories for people with early fatty liver disease. They will follow 177 adults aged 50 to 70 who are overweight, checking body fat, liver fat, and aging markers over a year. This is just the study plan, so no results are in yet. It aims to settle whether when you eat matters as much as how much.

## Practical Takeaway

This study may reveal if meal timing rivals calorie cutting for people with early fatty liver.

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