# Nicotinamide Riboside May Shield Female Mouse Muscle From Heat Damage

*Nicotinamide Riboside Supplementation Protects Against Heat-Induced Skeletal Muscle Injury in Female Mice.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Muscles (Basel, Switzerland)
- **Sample Size**: Female 6-week-old C57BL/6J mice
- **Authors**: Chen Y, Yu T
- **Published**: 2026-06-15
- **Topics**: nicotinamide riboside, NAD+, muscle health
- **DOI**: https://doi.org/10.3390/muscles5020044
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42347485/

## Summary

Heat stress can hurt muscle by triggering inflammation and damaging the cell's power plants. In female mice, the NAD+ booster nicotinamide riboside reduced that heat damage, calming inflammation and protecting mitochondria. Curiously, it worked without raising muscle NAD+ levels, so the benefit came through other paths.

## Practical Takeaway

This early mouse study suggests NR may protect muscle from heat stress, but human data is lacking.

---

_Canonical: https://longevity-austria.com/en/research/nicotinamide-riboside-may-shield-female-mouse-muscle-from-heat-damage · Part of Longevity Cities · Updated 2026-06-15_