Research Digest
Research Library
Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.
May 10–16, 2026
2 studiesBlood NAD+ Levels Stay Flat With Age, Challenging Popular Aging Theory
One of the most repeated ideas in longevity is that NAD+ declines as we age, a story that helped make NR and NMN household names in the space. This large, carefully controlled study takes a closer look. Across seven independent cohorts and more than 300 people, researchers found that whole-blood NAD+ levels stayed remarkably stable with age, and didn't shift meaningfully in response to exercise, protein-rich diets, or multimodal lifestyle interventions in older adults. Importantly, NR supplementation did raise blood NAD+ as expected, confirming that the supplements work pharmacologically, the question is just whether blood NAD+ is the right thing to be measuring in the first place.
Combining Wearables With Blood Proteins Sharpens Biological Age Tests
Researchers built a new biological age model that combines blood protein data with wearable device readings. It predicted mortality risk better than either tool alone and cut prediction error by 21%. The model also flagged common drugs like GLP-1 agonists and ACE inhibitors as linked to a younger biological age in specific organ systems.
Mar 22–28, 2026
2 studiesLab-on-a-Chip Mimics Decades of Human Aging in Just 4 Days
Researchers built a tiny organ-on-a-chip using human stem cells to model how fat tissue and the liver age together. By exposing it to blood serum from older people, the chip reproduced decades' worth of aging hallmarks in just 4 days. These included DNA damage and gene expression shifts seen in actual aged tissues. The system also revealed sex-based differences in aging and how fat aging spills over to affect the liver.
Anti-Inflammatory Foods May Lower Frailty Risk as You Age
Certain blood metabolites tied to fruits, vegetables, nuts, and legumes were linked to lower frailty risk in nearly 10,000 Canadian adults aged 45-85. The protective effect worked partly by reducing inflammation markers. On the flip side, a high omega-6 to omega-3 ratio and processed meat metabolites were tied to higher frailty risk through increased inflammation. The study tracked participants over three years, connecting dietary patterns to measurable metabolic changes.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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