Red Blood Cell Proteins Can Track Biological Aging and Predict Health a Decade Later

Preliminary Evidence·Cohort Study (Preprint)·bioRxiv : the preprint server for biology·Mar 2026

Researchers built a protein-based aging clock from the red blood cells of over 13,000 blood donors. People with conditions like G6PD deficiency and sickle cell trait showed accelerated molecular aging. Iron supplementation appeared to reverse some of that acceleration. The molecular age scores predicted real-world outcomes like hemolysis and donor activity over a 12-year follow-up.

Key Insight

This study suggests red blood cell proteins could serve as accessible markers of biological aging.

Original Paper

bioRxiv : the preprint server for biology··13,091 blood donors with longitudinal follow-up

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