41 Studien

Forschungsbibliothek

Peer-reviewed Papers aus Top-Journals, zusammengefasst und nach Evidenzstärke bewertet. Updates jeden Mo, Mi & Fr.

4/41

We May Not Be Aging Slower. We're Just Starting Later.

A big question in longevity research is whether rising life expectancy means we're actually aging more slowly. This analysis of mortality data from 12 countries suggests the answer is no. After accounting for historical shocks like wars and pandemics, the rate at which aging accelerates after 80 hasn't changed. The gains in lifespan appear to come from pushing back when serious aging begins, not from slowing the process itself.

Proceedings of the National Academy of Sciences of the United States of America·Moderat·8. Apr. 2026

Centenarians Show a Distinct Metabolic Profile Tied to Bile Acids and NAD+

People who live past 100 have a unique metabolic fingerprint. In a study of 213 participants from the New England Centenarian Study, extremely long-lived individuals had higher levels of certain bile acids and lower levels of bilirubin compared to younger controls. Higher bile acid and steroid levels were linked to lower mortality risk. The researchers also built a "metabolomic clock" that estimates biological age, and deviations from it predicted death risk.

GeroScience·Moderat·26. März 2026

Frailty Triples Death Risk, and Exercise Alone May Not Fix It

Frail adults in South Korea had over three times the mortality risk compared to robust individuals over a 16-year follow-up. Pre-frail people also had about 70% higher risk. Meeting standard exercise guidelines (150 minutes per week) didn't independently lower death risk in pre-frail or frail individuals after accounting for other factors. Frail participants who met those guidelines actually had higher healthcare costs, suggesting generic exercise advice may not suit everyone.

The Journal of frailty & aging·Moderat·18. März 2026

Frailty Markers Predict 20-Year Death Risk in Older Chinese Adults

In about 4,000 older Hong Kong adults tracked for nearly two decades, frailty measures strongly predicted who would die and from what cause. Being frail was linked to a 66% higher risk of death compared to being fit. Adding blood-based markers like inflammation and kidney function to frailty scores slightly improved predictions. One surprise: none of the biological aging markers predicted cancer deaths specifically.

The journals of gerontology. Series A, Biological sciences and medical sciences·Stark·12. März 2026

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