Caloric restriction and biological age
2 papers in the library, strongest Strong.
Graded Strong · Pooled analysis of seven randomized caloric restriction trials with 829 adults, though the outcome was a composite biomarker index rather than clinical aging outcomes.
Papers 2
- Cutting Calories Improves Aging Markers, Only Half From Weight LossStrongn = 8292026GeroScienceWhen older adults cut calories, their blood markers of inflammation, kidney health and insulin all moved in a younger direction. The surprise: only about half of that benefit could be traced back to the pounds they lost. This hints that eating less does something to the body beyond simple slimming down. The data came from pooling seven randomized calorie restriction trials in adults.
- Caloric Restriction Slows Aging Most in the Heart and MetabolismStrongn = 1852026Clinical nutrition (Edinburgh, Scotland)Cutting calories doesn't slow aging evenly across all organs. In a two-year trial, 185 adults were randomly assigned to caloric restriction or normal eating. The caloric restriction group aged about one year less in their cardiovascular and metabolic systems over 24 months. Kidney aging, however, didn't budge, and liver aging only slowed modestly at the two-year mark.
How this map is computed
A mark's size is the number of papers we hold on that pairing. It is a count, not a weighting by study design or sample size.
The fill shows the strongest grade in the cell. One Strong paper among four Preliminary ones still fills it dark, so open the cell to see the rest.
Grades and verdicts are assigned by a named person, never by counting.
An empty cell is a finding: nobody in our library has run that trial yet.