Fatty Liver: Weight-Loss Thresholds Differed by Genes and Sex
Graded Moderate — a prospective UK Biobank analysis of nearly 18,000 people, but with a median four years of follow-up, observational data and model-estimated thresholds.
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- 11,882
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Weight-loss thresholds linked to fatty liver resolution differed by genetic profile, metabolic risk and sex.
How much weight loss went along with a healthier liver varied with a person's genes, metabolic risk and sex. The study looked at MASLD, a fatty liver disease driven by metabolic problems, using UK Biobank data over a median of four years. Each percent of body weight lost was linked to fewer new cases, and among people with the disease, to more frequent resolution. The estimated thresholds varied widely: in the group with high genetic liver risk, they were 5.3 percent for men and 13.3 percent for women. These figures are statistical estimates from observational data, not targets tested in a trial.
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