What is the Longevity Research Library?

The Longevity Austria Research Library curates recent peer-reviewed studies on longevity, nutrition, exercise, sleep, and supplements. Each study is rated by evidence strength: Strong, Moderate, or Preliminary.

How are evidence levels determined?

Evidence levels are based on study type (meta-analysis, RCT, cohort study), sample size, journal impact factor, and reproducibility of findings.

79 studies

Research Library

Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.

8/79

May 10–16, 2026

Why 17α-Estradiol Extends Lifespan in Male Mice but Not Females

17α-estradiol is a quirky cousin of the main estrogen hormone, and in mice it stretches lifespan and improves metabolism only in males. It trims body fat, sharpens insulin sensitivity, and protects the liver, with just mild feminizing effects. Scientists still don't fully know why males benefit and females don't. This is early-stage animal research, not yet ready for humans.

Ageing research reviews·Preliminary·May 15, 2026

Apr 26 – May 2, 2026

Stress Response Trade-Off: Less ATF4 Activity May Extend Lifespan in Flies

Scientists used to think turning on the body's stress response made organisms live longer. But in fruit flies, the opposite was true. When researchers dialed down a key stress pathway called GCN2-ATF4, flies lived longer. Cranking it up shortened their lives. This complicates the popular idea that all forms of cellular stress activation are good for aging.

Proceedings of the National Academy of Sciences of the United States of America·Preliminary·Apr 28, 2026

Apr 12–18, 2026

Your Blood Is Both a Mirror and a Driver of How Fast You Age

Scientists are finding that the stuff floating in your blood, proteins, metabolites, and tiny vesicles, doesn't just reflect your age. It actively sets the pace of aging across organs. In animal studies, swapping old blood for young blood or filtering out pro-aging factors restored tissue function and even extended lifespan. Human trials using plasma exchange are now showing early promise for age-related decline.

Experimental & molecular medicine·Moderate·Apr 17, 2026

Quail Bred to Reproduce More Aged Faster, Supporting a Core Theory of Aging

Researchers selectively bred Japanese quail for higher or lower reproductive effort across several generations. By generations five and six, the high-reproduction birds died sooner. The lifespan difference came from faster aging rates, not from being more fragile to begin with. This is some of the cleanest experimental evidence in vertebrates that investing more in reproduction comes at a real cost to longevity.

Proceedings. Biological sciences·Moderate·Apr 15, 2026

Apr 5–11, 2026

We May Not Be Aging Slower. We're Just Starting Later.

A big question in longevity research is whether rising life expectancy means we're actually aging more slowly. This analysis of mortality data from 12 countries suggests the answer is no. After accounting for historical shocks like wars and pandemics, the rate at which aging accelerates after 80 hasn't changed. The gains in lifespan appear to come from pushing back when serious aging begins, not from slowing the process itself.

Proceedings of the National Academy of Sciences of the United States of America·Moderate·Apr 9, 2026

Mar 22–28, 2026

Fat Tissue Controls Lifespan Through Insulin Signaling in Fruit Flies

In fruit flies, dialing down a gene called Dicer-1 in fat tissue extended lifespan. It worked even when flies were already on calorie restriction. The mechanism involves a chain reaction: lower Dicer-1 reduces a small RNA molecule in fat, which boosts a hormone that then tells the brain to release less insulin. Less insulin signaling is a well-known longevity pathway across species.

Proceedings of the National Academy of Sciences of the United States of America·Preliminary·Mar 24, 2026

Mar 15–21, 2026

Eight Hyped Compounds Failed to Extend Lifespan in a Major Mouse Study

The NIA's Interventions Testing Program tested eight compounds across three lab sites in genetically diverse mice. None extended lifespan. That includes astaxanthin, alpha-ketoglutarate, pioglitazone, atorvastatin-telmisartan, and others with prior promising results. Some compounds previously shown to work at different doses or start ages didn't replicate under new conditions. Two drugs actually shortened lifespan in female mice.

GeroScience·Strong·Mar 17, 2026

Mar 8–14, 2026

How Your Immune System Rewires Itself from Birth to Old Age

Researchers mapped immune cells at the single-cell level across the human lifespan, from mid-fetal development through late adulthood. T cells showed the biggest age-related changes. A specific subset of CD8 memory T cells appeared protective in young adults, while inflammatory monocytes ramped up with aging. A previously unknown subset of immune-suppressing natural killer cells was especially common in early childhood.

Cell reports·Preliminary·Mar 10, 2026

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.

Your Weekly Edge

Receive the latest longevity insights, exclusive event invites, and science-backed tips to help you live longer and thrive.