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Nutrition & supplements

Coenzyme Q10

DECoenzym Q10

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Coenzyme Q10 (ubiquinone) is a lipid-soluble molecule essential for mitochondrial electron transport and ATP production, and an intracellular antioxidant. Endogenous levels decline with age and with statin use. Clinical evidence is strongest in heart failure: in the Q-SYMBIO trial (300 mg/day), CoQ10 reduced all-cause mortality and major cardiovascular events in chronic heart failure patients; however, replication has been inconsistent and most other trials have been smaller. Effects on blood pressure and statin-related muscle symptoms are modest; longevity benefits in healthy adults are not established.

Sources

  1. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, et al.. (2014). The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. *JACC: Heart Failure*doi:10.1016/j.jchf.2014.06.008