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Journal ArticleProceedings of the National Academy of Sciences of the United States of America·Jun 2026

A New Drug Combo May Protect Muscle During Ozempic-Style Weight Loss

Drugs like semaglutide help people lose weight but often shrink muscle too. In obese mice, adding an experimental compound called a 15-PGDH inhibitor helped muscles repair and regrow after injury, without canceling out the weight loss. This points to a possible way to keep muscle while on GLP-1 drugs.

Conflict of Interest Disclosure: One author consults for and holds patents licensed to Epirium Bio; another co-founded Merrifield Therapeutics.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.