A New Drug Combo May Protect Muscle During Ozempic-Style Weight Loss

Based on: 15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss.

Preliminary Evidence·Journal Article·Proceedings of the National Academy of Sciences of the United States of America·Jun 2026

Drugs like semaglutide help people lose weight but often shrink muscle too. In obese mice, adding an experimental compound called a 15-PGDH inhibitor helped muscles repair and regrow after injury, without canceling out the weight loss. This points to a possible way to keep muscle while on GLP-1 drugs.

Original Paper

Nalbandian M, Lone J, Le Moal E, Kim I, Jeuris K, Li YK, Kraft P, Zhao M, Koleckar K, Zhang Z, Svensson KJ, Blau HM

Proceedings of the National Academy of Sciences of the United States of America··Obese mice (number not specified)

Conflict of Interest Disclosure: One author consults for and holds patents licensed to Epirium Bio; another co-founded Merrifield Therapeutics.

View on PubMedFull Paper (DOI)
GLP-1musclesemaglutide

Related Studies

protein

Why Standard Protein Advice May Fall Short for Older Adults

This review argues that general protein guidelines may not be enough for older adults trying to keep their muscle. Older bodies need more protein, spread evenly through the day, with a focus on leucine-rich foods like animal proteins. The authors note that creatine, vitamin D, collagen, and omega-3s, combined with resistance training, may further support muscle health.

Frontiers in nutrition·Moderate·May 8, 2026

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.